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. Author manuscript; available in PMC: 2017 Jan 3.
Published in final edited form as: Cell Rep. 2016 Nov 1;17(6):1560–1570. doi: 10.1016/j.celrep.2016.10.017

Figure 3. The Role of the CDRH3 Sequence on the Binding of Germline 02-CB Antibody to Env.

Figure 3

(A) The CDRH3 sequences of iglVRC01 and 02-CB antibodies, as well as the reverting mutations (highlighted in orange) introduced in the 02-CB CDRH3 region are shown. Trp100BHC is highlighted in yellow. Residues that make direct contact with Env are indicated by asterisks.

(B and C) Binding to the C4b particles (7-mer) (B) and Ferritin particles (24-mer) (C) expressing 426c degly-3 core gp120. Vertical dotted lines indicate the start of the dissociation phases.