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. 2016 Oct 27;291(50):26083–26097. doi: 10.1074/jbc.M116.757138

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — RNA interference against β-arrestin1 or STAM1 attenuates CXCR4-promoted autophosphorylation of FAK. HeLa cells transfected with β-arrestin1 siRNA (A) or STAM1 shRNA (B) were treated with 10 nm CXCL12 for 5 min and analyzed as in Fig. 5A. Representative immunoblots from five (A) or seven (B) independent experiments are shown. Graphs represent the densitometric analyses showing the relative levels of Tyr(P)-397-FAK (pFAK) compared with the control (siCtrl in A or pLKO in B)-transfected cells treated with CXCL12. The error bars represent the S.D. Data were analyzed by two-way ANOVA and Newman-Keuls multiple comparison test. p values between the indicated groups are shown.