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An overview of the full story. Proteasome inhibition induces the phosphorylation of HSF1 and its translocation into the nucleus. In addition to trimeric HSF1 binding to HSE, which initiates HIV transcription, HSF1 recruits p-TEFb to phosphorylate RNA pol II thus promoting transcription elongation. The reactivation process is facilitated by generating HSP90 that binds to CDK9 to prevent it from degradation by the proteasome, thereby giving positive feedback to HSF1.
