Figure 2b:
Cardiac CEST images show how the rejection of implanted Eu-HP-DO3A–labeled cells in C57BL/6J mice leads to elimination of initial CEST contrast. (a) Implantation of Eu-HP-DO3A–labeled cells in a representative C57BL/6J mouse resulted in increased MTRasym values in the lateral ventricular wall in close proximity to the inferior papillary muscle 24 hours after implantation (arrow), similar to that observed in C3H mice. (b) However, at 20 days after implantation, MTRasym values in the same myocardial region (arrow) decreased and were indistinguishable from surrounding myocardium.