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. 2016 Nov 7;291(53):27334–27342. doi: 10.1074/jbc.M116.743849

TABLE 2.

Embryonic development after the microinjection of LNA

Note: values with different superscripts within columns denote significant differences (p < 0.05).

Groups Repeats Embryos Blastocyst (%) Embryos arrested at two/four-cell stage (%)
NT Con 3 101 18 (17.46 ± 4.55)a 31 (32.76 ± 5.78)a
REST-LNA 3 98 3 (3.06 ± 0.12)b 60 (60.39 ± 5.21)b
Con-LNA 3 102 16 (15.37 ± 4.72)a 29 (27.39 ± 4.21)a
Con 4 160 21 (12.24 ± 4.08) 74 (44.25 ± 11.78)

IVF REST-LNA 4 160 19 (10.38 ± 4.60) 75 (46.47 ± 11.33)
Con-LNA 4 160 26 (15.82 ± 6.86) 79 (50.35 ± 8.33)
Con 3 98 24 (24.35 ± 5.52) 20 (22.56 ± 2.61)

ICSI REST-LNA 3 86 19 (22.86 ± 2.98) 23 (27.32 ± 2.22)
Con-LNA 3 92 22 (25.32 ± 4,73) 22 (24.28 ± 5.08)