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X-ray crystal structure of PRMT1-SAH-Arg complex (Protein Data Bank ID: 1OR8). A, PRMT1 is shown in ribbon mode with the N-terminal αX helix (blue), αY helix (pink), Rossmann fold (cyan), β-barrel (gray), and dimerization arm (green). The αX helix is invisible in the original crystal structure and was homology-modeled from our previous work (15). B, binding pocket for SAH and Arg (without αX helix). Tryptophan residues, SAH, and substrate Arg are shown in stick mode.
