FIGURE 5.

WZB117 is without effect on [³H]CB binding to human RBCs (●) but serves as a low affinity inhibitor of CB binding to red cell membranes depleted of peripheral membrane proteins (○). The lines drawn through the points were computed by linear regression. K_i(app) for inhibition of CB binding is computed as the -x-intercept. The results are: RBCs (●) K_i(app) = 373 ± 310 μm, R² = 0.238, p value testing the null hypothesis that the overall slope is zero = 0.2765; membranes (○) K_i(app) = 150.4 ± 24.4 μm; R² = 0.943, p value testing the null hypothesis that the overall slope is zero = 0.0058.