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STING mediates pro-apoptotic activation of IRF3 in a chronic CCl4-induced model of fibrosis. WT or STING-deficient mice (Tmem173Gt) were injected with oil or CCl4 for 6 weeks and sacrificed. Whole cell liver lysates were probed for phosphorylated TBK1 (A), phosphorylated IRF3 (B), cleaved caspase-8 (C), and cleaved caspase-3 (D) by immunoblot. n = 8–9 mice (CCl4-treated, per genotype); 3–4 mice (oil-treated, per genotype).
