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. 2016 Nov 10;291(52):26806–26815. doi: 10.1074/jbc.M116.751040

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Effect of replacing the ER-localization of viperin on its activity against FPPS. The levels of FPPS were quantified in HEK293T cells transfected with FPPS; co-transfected with wild-type viperin; co-transfected with viperin lacking the N-terminal ER-localization sequence (TN50); and co-transfected with viperin in which the ER-targeting sequence the viral protein NS5A replaces endogenous ER-targeting sequence (NS5A-TN50). Neither the truncated enzyme nor the chimeric enzyme is able to reduce the cellular levels of co-expressed FPPS. The data are plotted showing the means and standard deviation of three independent biological replicates. *, p < 0.05.