FIGURE 6.

ERK1/2 inhibition during AKI attenuates an increase in serum creatinine and increases PGC-1α and TFAM proteins. A, representative immunoblot of phosphorylated ERK1/2, total ERK1/2, TFAM, and PGC-1α following IR AKI. p, phosphorylated; MW, molecular weight. B, mRNA expression of PGC-1α and NRF1 following IR AKI at 3 h after IR in the kidney cortex. C and D, densitometry analysis of PGC-1α (C) and TFAM (D) proteins following 3 h IR. E, serum creatinine was assessed 3 h after IR AKI. Data are represented as mean ± S.E., n ≥ 5. Different superscripts indicate statistically significant differences (p < 0.05).