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. Author manuscript; available in PMC: 2017 Jan 3.
Published in final edited form as: J Phys Chem B. 2016 Apr 13;120(26):6120–6129. doi: 10.1021/acs.jpcb.6b02163

Figure 6.

Figure 6

Simulation of the effect of cellular uptake on the concentration distribution of high aspect ratio (L/d = 300/18) TMV within the spheroid. Top 3 panels are 2D plots of the concentration of TMV formulations as a function of the radial distance within the spheroid for specific time interval (1 h, 2 h, 6 h, 12 h, 18 h, 24 h), and the bottom 3 panels are the corresponding 3D plots of the concentration of TMV as a function of both time and radial distance. Cell density ϕ = 0.5, spheroid radius R = 200 µm, TMV concentration in the surrounding medium CM = 0.1 mg/mL.