Fig. 11.
A fumigatus schA contributes to virulence in neutropenic mice.
A. Comparative analysis of wild-type and the mutants strains in a neutropenic murine model of pulmonary aspergillosis. Mice in groups of 10 per strain were infected intranasally with a 20 µl suspension of conidia at a dose of 105.
B. Histological analyses of infection murine lung were performed 72 h after infection (C) Fungal burden was determined 72 h post infection by qPCR based on 18S rRNA gene of A. fumigatus and an intronic region of the mouse GAPDH gene.