FIGURE 1.

LDHB expression is induced by exercise in human muscle and negatively correlated with changes in intramuscular pH levels during muscle contraction. Samples from 4–8 active and 15–17 healthy sedentary controls were used for this analysis. mRNA expression levels of LDHB, LDHA, and PPARGC1A was determined by qRT-PCR. The data represent the means ± S.E. A, LDHB and LDHA expression in sedentary and active human muscle analyzed using a two-sample t test (n = 8–17). **, p < 0.01 versus sedentary controls. B, skeletal muscle LDHB and LDHA expression pre- and postexercise training of lean sedentary subjects. The differences were analyzed using paired Student's t test (n = 13). *, p < 0.05. C, Spearman correlation between LDHB and LDHA gene expression and PPARGC1A. D, Pearson correlation between LDHB and LDHA gene expression and ΔpH (changes in pH levels).