Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Isothermal titration calorimetry affinity measurements. A, binding isotherm measured at 295 K for the interaction between cAMP and apo-PfPKA-R.141.441; below is the resulting thermogram obtained from the integrated heats using a one-site binding model. Equivalent experiments for binding to the CBD2 site of apo-PfPKA-R.297.441 are shown for cAMP (B), (Sp)-2-Cl-cAMPS (C), and(Sp)-8-Br-cAMPS (D).
