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Foxo3b is required for hypoxia tolerance in zebrafish. Three groups of foxo3b-null zebrafish fry (15 dpf, 20/group) and their wild-type siblings (15 dpf, 20/group) were placed in the hypoxia chamber (Ruskinn INVIVO2400). The oxygen concentration was adjusted to 2% O2 ahead of time. The dead fry counted once an hour until the death of the last fry with one genotype (foxo3b−/−).
