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. 2016 Oct 24;291(49):25692–25705. doi: 10.1074/jbc.M116.745471

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 9. — Zebrafish foxo3b suppresses hypoxia-induced gene expression. A, foxo3b-null embryos (foxo3b^−/−) exhibit higher vegf expression compared with their wild-type siblings (foxo3b ^+/+) under normoxia and hypoxia. B, foxo3b-null embryos (foxo3b^−/−) exhibit higher pou5f1 expression compared with their wild-type siblings (foxo3b ^+/+) under normoxia and hypoxia. C, foxo3b-null embryos (foxo3b^−/−) exhibit higher pai1 expression compared with their wild-type siblings (foxo3b ^+/+) under normoxia and hypoxia. D, foxo3b-null embryos (foxo3b^−/−) exhibit higher il11a expression compared with their wild-type siblings (foxo3b ^+/+) under normoxia and hypoxia. E, foxo3b-null embryos (foxo3b^−/−) exhibit higher vegf expression compared with their wild-type siblings (foxo3b ^+/+) with or without DMOG (100 μm) treatment. F, foxo3b-null embryos (foxo3b^−/−) exhibit higher pai1 expression compared with their wild-type siblings (foxo3b ^+/+) with or without DMOG (100 μm) treatment.