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. 2016 Dec 28;11:103–121. doi: 10.2147/DDDT.S115135

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© 2017 Iman et al. This work is published and licensed by Dove Medical Press Limited

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Western blotting analysis of girinimbine-treated HT-29 cells.

Notes: (A) Expressions of Bcl-2, Bax, p21, p27, and p53 against β-actin. (B) Expressions of caspase 9, cleaved caspase-9, caspase 3 and cleaved caspase-3 against β-actin. Cells were exposed to girinimbine at the IC₅₀ concentration for 12, 24, and 48 hours. Girinimbine treatment up-regulated the expressions of Bax, p21, p27, p53, caspase 9, caspase 3, cleaved caspase-9 and cleaved caspase-3 compared to the untreated control in a time dependent manner. In contrast, Bcl-2 expression was down-regulated for the same time period.