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. Author manuscript; available in PMC: 2017 Aug 16.
Published in final edited form as: Immunity. 2016 Aug 2;45(2):374–388. doi: 10.1016/j.immuni.2016.07.009

Figure 5. PD-1 Blockade Does Not Rescue Metabolic Dysfunction in Intratumoral T Cells.

Figure 5

(A) Representative flow cytogram of CD8+ T cells from LN and TIL preparations in B16-bearing mice receiving thrice-weekly injections of 200 µg anti-PD1 or its isotype control.

(B) Tabulated results from (A) as well as MC38-bearing mice. Each dot represents a mouse in this experiment.

(C) Percentage of mice experiencing tumor regression in several experiments conducted as in (B).

(D) Flow cytogram and tabulated values of MitoTracker FM staining during cell division of OT-I T cells transferred into established B16OVA tumors under the cover of anti-PD1 or its isotype control. Data are representative of five (A and B) or represent the mean of three (C and D) independent experiments. Error bars indicate SEM. See also Figure S5.