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. 2016 Sep 14;13(12):1286–1299. doi: 10.1080/15476286.2016.1232238

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 7. — Dis3L2 and Pacman function in distinct pathways to control wing development. (A) Knockdown of dis3L2 in the hypomorphic pcm⁵ mutant background results in a compensatory phenotype in that the wing area returns to wild type size. n ≥ 15, error bars represent 95% confidence limits, **** = p < 0.0001. (B) Knockdown of dis3L2 in the null pcm¹⁴ mutant background results in a compensatory phenotype in that the wing imaginal disc area returns to wild type size. n ≥ 15, error bars represent 95% confidence limits, **** = p < 0.0001. (C) Knockdown of dis3L2 in pcm¹⁴ mutant wing discs (pcm¹⁴ Dis3L2^KD) has no effect on the post-transcriptional upregulation of rpr. pre-rpr (light gray) used to detect the level of transcription of rpr. n ≥ 3, error bars represent SEM, *** = p < 0.001, * = p < 0.05. (D) dis3L2 knockdown (Dis3L2^KD) has a larger effect on wing overgrowth than the Df(3L)H99 mutation as a heterozygote (Control Df(3L)H99). However, knocking down dis3L2 in a heterozygous Df(3L)H99 background (Dis3L2^KD Df(3L)H99) results in an additive effect where the wings are significantly larger than dis3L2 knockdown wings alone. n ≥ 18, error bars represent 95% confidence limits, **** = p < 0.0001. (E) Knockdown of dis3L2 in pcm¹⁴ mutant wing discs (pcm¹⁴ Dis3L2^KD) has no effect on the post-transcriptional upregulation of dilp8. pre-dilp8 (light gray) used to detect the level of transcription of dilp8. n ≥ 3, error bars represent SEM, **** = p < 0.0001. Full details of the genotypes are provided in the Materials and Methods section.