Figure 1.

Changes in mRNA levels and turnover rates in growing yeast. (A) There is a constant mRNA concentration for most conditions with a change in GR (represented as a yeast cell population with variable budding index).¹⁵ Increasing mRNA turnover (resulting from parallel transcription and decay rates) accompanies an increase in GR (see²⁶ for discussion). (B) Under steady-state conditions some gene functional groups change [mRNA] with GR by uncoupling the equilibrium between synthesis and decay rates. Three representative gene groups with different strategies are shown: protein biosynthesis, stress-induced and mitochondria-related genes (see text for discussion).