Fig 1. Induction of TSP-1 via multiple mechanisms by hypoxia and TGFβ signaling.

An increase in the abundance of translatable TSP-1 mRNA in hypoxia results from the regulation by different pathways. Arrow symbol denotes activation, ⊣ symbol denotes repression. MicroRNAs that target TSP-1 (e.g. miR-18a) are less abundant in hypoxic conditions, together with the activation of different TSP-1 promoters, lead to an increase in intracellular TSP-1 production.