Table 3.

Fluctuation index and stability index

	Before cataract surgery (1)	Four weeks after surgery (2)	After DQS/AT instillation (3)
Total fluctuation index
DQS
EM mean (95% CI)	0.025 (0.016–0.040)	0.029 (0.018–0.047)	0.017 (0.010–0.023)
P-value (1 vs 2; 1 vs 3; 2 vs 3)	0.637; 0.186; 0.087
AT
EM mean (95% CI)	0.032 (0.021–0.049)	0.029 (0.019–0.045)	0.049 (0.032–0.075)
P-value (1 vs 2; 1 vs 3; 2 vs 3)	0.717; 0.132; 0.071
DQS vs AT
P-value	0.438	0.976	0.004**
P-value for interaction	0.020*
Total stability index
DQS
EM mean (95% CI)	0.002 (−0.002–0.007)	0.007 (0.002–0.012)	0.001 (−0.004–0.005)
P-value (1 vs 2; 1 vs 3; 2 vs 3)	0.163; 0.588; 0.054
AT
EM mean (95% CI)	0.004 (0.000–0.008)	0.004 (0.000–0.008)	0.01 (0.006–0.014)
P-value (1 vs 2; 1 vs 3; 2 vs 3)	0.958; 0.046*; 0.041*
DQS vs AT
P-value	0.598	0.332	0.004**
P-value for interaction	0.016*

Notes: DQS or AT was instilled from the visit 4 weeks after cataract surgery for 4 weeks. Mixed model post hoc test with Bonferroni correction:

^*P<0.05;

^**P<0.01.

Abbreviations: AT, artificial tears; CI, confidence interval; DQS, diquafosol sodium ophthalmic solution; EM mean, estimated marginal mean.