Table S2.
Predictors of bad outcome (BCVA >1 logMAR)
| Variables | Univariate
|
Multivariate
|
||||
|---|---|---|---|---|---|---|
| OR | 95% CI | Significance | OR | 95% CI | Significance | |
| Right eye | 0.587 | 0.241–1.432 | P=0.241 | NI | ||
| Hypercholesterolemia | 0.628 | 0.270–1.457 | P=0.278 | NI | ||
| Hypertension | 0.773 | 0.317–1.882 | P=0.570 | NI | ||
| Number of HBOT sessions | 0.819 | 0.577–1.1162 | P=0.263 | NI | ||
| Previous aspirin | 0.836 | 0.360–1.940 | P=0.676 | NI | ||
| Sex | 0.948 | 0.386–2.331 | P=0.908 | NI | ||
| Diabetes mellitus | 0.975 | 0.350–2.711 | P=0.961 | NI | ||
| IOP | 0.989 | 0.902–1.084 | P=0.812 | NI | ||
| Age | 1.015 | 0.984–1.048 | P=0.677 | NI | ||
| Previous statin | 1.04 | 0.424–2.547 | P=0.932 | NI | ||
| Time delay symptoms to Tx | 1.125 | 0.985–1.285 | P=0.083 | NI | ||
| Plaque in fundus | 1.143 | 0.349–3.741 | P=0.825 | NI | ||
| Massage | 1.225 | 0.470–3.195 | P=0.678 | NI | ||
| Other vasculopathy | 1.317 | 0.407–4.265 | P=0.646 | NI | ||
| Stroke | 1.444 | 0.298–7.010 | P=0.648 | NI | ||
| Active smoking | 1.687 | 0.654–4.354 | P=0.279 | NI | ||
| Ischemic heart disease | 1.725 | 0.638–4.670 | P=0.283 | NI | ||
| Boxcarring in fundus | 1.792 | 0.564–5.697 | P=0.323 | NI | ||
| Paracentesis | 2.602 | 1.049–6.457 | P=0.039 | NI | ||
| Aspirin | 2.67 | 0.324–22.029 | P=0.362 | NI | ||
| Acetazolamide PO | 2.778 | 0.772–9.993 | P=0.118 | NI | ||
| Acetazolamide E | 2.854 | 0.620–13.126 | P=0.178 | NI | ||
| Previous anti-coagulation | 3.000 | 0.367–24.502 | P=0.305 | NI | ||
| Baseline logMAR | 6.115 | 2.488–15.029 | P<0.0001 | 3.993 | 1.277–12.490 | P=0.017 |
| Cherry-red spot | 25.579 | 7.935–82.455 | P<0.0001 | 16.488 | 4.857–55.979 | P<0.0001 |
Notes: Baseline BCVA and presence of CRS at presentation were the only significant variables after multivariate analysis. The fundus finding of CRS at presentation was the strongest predictor with OR of 16.488 for a bad outcome. Bold text marks statistical significance (P<0.05).
Abbreviations: BCVA, best-corrected visual acuity; logMAR, logarithm of the minimum angle of resolution; OR, odds ratio; CI, confidence interval; NI, not included in multivariate analysis due to non-significance; HBOT, hyperbaric oxygen therapy; IOP, intraocular pressure; Tx, treatment; CRS, cherry-red spot; PO, per oral; E, eye drops.