Table 3. Evaluation of nucleophile scope ^a .

^aIsolated yields and ee's are the average of two runs on a 0.5 mmol scale with 3 equiv. RZnBr.

^bReaction was run with 20 mol% Ni(acac)₂ and 24 mol% L3.

^cReaction was run with RZnI.

^dYield and ee determined after Pd/C-catalyzed hydrogenation to the piperidine.

^eReaction was run with 1.25 equiv. i-BuOCOCl.

^fReaction was run from –78 °C → rt.