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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Neuropharmacology. 2016 Jul 29;111:304–313. doi: 10.1016/j.neuropharm.2016.07.034

Figure 3. Voltage-sensitive dye imaging shows haloperidol increases the spread of activity in CA1 in slices from PGC-1α+/+ mice but decreases spread of activity in slices from PGC-1α−/− mice.

Figure 3

A. Example image time sequence of the spatiotemporal pattern of VSD signals in CA1 from PGC-1α+/+ slice (left) and PGC-1α+/+ slice treated with 1 µM haloperidol (right) in response to single pulse stimulation of SC axons at 70 µA. Each frame is 2.49 ms apart. B–D. Quantification of haloperidol effects on maximum peak (B, n=7, two-way ANOVA, F(3,28)=23.1, * = p<0.05), spread (C, (n=7, two-way ANOVA, F(3,28)=14.3, * = p<0.05), and duration (D, n=7) in PGC-1α+/+ slices. E. Example image time sequence of the spatiotemporal pattern of VSD signals evoked in CA1 from PGC-1α−/− slice (left) and PGC-1α−/−slice treated with 1 µM haloperidol (right) in response to single pulse stimulation of SC axons at 70 µA. F–H. Quantification of haloperidol effects on maximum peak (F, n=9, *=p<0.05), spread (G, n=9, *=p<0.05), and duration (H, n=9, two-way ANOVA, F(3,28)=40.3, * = p<0.05) in PGC-1α−/− slices.