Table 6.
MMRM and LOCF_ANCOVA analyses of VAS overall pain severity in Studies 1 and 2.
| STUDY 1 | STUDY 2 | ||||||||
| MMRM | |||||||||
| THERAPY | Week | N | Mean change | Std.error | p-value | N | Mean change | Std.error | p-value |
| DULOX | 1 | 120 | -2.69 | 1.97 | .181 | 121 | -2.02 | 1.89 | .157 |
| PLACEBO | 1 | 113 | 1.04 | 2.04 | 134 | 1.38 | 1.79 | ||
| DULOX | 2 | 113 | -8.20 | 1.87 | .003 | 108 | -6.95 | 2.04 | .003 |
| PLACEBO | 2 | 108 | -0.42 | 1.93 | 127 | 0.91 | 1.90 | ||
| DULOX | 3 | 105 | -10.46 | 1.95 | .005 | 106 | -9.81 | 1.90 | < .001 |
| PLACEBO | 3 | 101 | -2.56 | 2.01 | 119 | -1.59 | 1.78 | ||
| DULOX | 5 | 99 | -8.68 | 2.20 | .028 | 95 | -9.70 | 2.05 | .011 |
| PLACEBO | 5 | 99 | -1.85 | 2.24 | 108 | -2.92 | 1.92 | ||
| DULOX | 7 | 91 | -10.25 | 2.34 | .016 | 87 | -8.91 | 2.12 | .254 |
| PLACEBO | 7 | 92 | -2.26 | 2.38 | 94 | -5.76 | 2.01 | ||
| DULOX | 9 | 83 | -8.68 | 2.18 | .055 | 80 | -10.05 | 2.24 | .135 |
| PLACEBO | 9 | 88 | -2.80 | 2.20 | 88 | -5.65 | 2.12 | ||
| LOCF_ANCOVA | |||||||||
| DULOX | LOCF_ANCOVA | 121 | -8.31 | 2.09 | .019 | 121 | -10.39 | 2.05 | .037 |
| PLACEBO | LOCF_ANCOVA | 114 | -1.40 | 2.18 | 134 | -5.22 | 1.94 | ||