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. 2017 Jan 3;12(1):e0169229. doi: 10.1371/journal.pone.0169229

Fig 1. Effect of NVP-AEW541 on proliferation and levels of IGF-1R and Akt in MDA-MB-231 and BT-549 cells.

Fig 1

(A) Western blotting validated that NVP-AEW541 significantly reduced expression of phosphorylated IGF-1R and Akt. One representative from three independent experiments is shown. (B-D) NVP-AEW541 markedly decreased the proliferation rate of MDA-MB-231 and BT-549 cells, as assessed by EdU (B and C) and cell counting kit-8 assays (D). Results were obtained from at least four independent experiments, and data are presented as the mean ± SD, *p<0.05, **p<0.01, ***p<0.001.