Table 4. Titrations of Diagnostic/Death Criteria for Simulated Clinical Trials.
| Trial Group | Group Size | Motility Phenotype | Diagnostic/Treatment Criteria | Death Criteria | Median Survival Time |
|---|---|---|---|---|---|
| Highly Dispersive + Angiogenesis | 25 | CoD: High HD: High |
% Vascular Proliferation: {1.0, 1.5, 2.0, 2.5, 3.0} | % FLAIR: {62, 63, 64, 65, 66} | 14.5 mo |
| Moderately Dispersive + Angiogenesis | 25 | CoD: Moderate HD: Hig |
% Vascular Proliferation: {1.0, 1.5, 2.0, 2.5, 3.0} | % Radiological Necrosis: {3.4, 3.8, 4.2, 4.6, 4.8} | 5.5 mo |
| HD +Angiogenesis | 25 | CoD: Low HD: High |
% Vascular Proliferation: {1.0, 1.5, 2.0, 2.5, 3.0} % Radiological Necrosis {0.5, 0.75, 1, 1.25, 1.5} |
% Radiological Necrosis: {3.4, 3.8, 4.2, 4.6, 4.8} | 6.6 mo |
| Control (Untreated) | 25 | CoD: High HD: High |
% Vascular Proliferation: {1.0, 1.5, 2.0, 2.5, 3.0} | % Vascular Proliferation: {15, 17, 19, 21, 23} | 3.2 mo |
| 25 | CoD: Moderate HD: High |
% Vascular Proliferation: {1.0, 1.5, 2.0, 2.5, 3.0} | % Vascular Proliferation: {15, 17, 19, 21, 23} | ||
| 25 | CoD: Low HD: High |
% Vascular Proliferation: {1.0, 1.5, 2.0, 2.5, 3.0} % Radiological Necrosis {0.5, 0.75, 1, 1.25, 1.5} |
% Radiological Necrosis: {3.4, 3.8, 4.2, 4.6, 4.8} |
CoD: Concentration-Driven. HD: Hypoxia-Driven.