Fig 7. Effects on the levels of the proteins p-Akt and p-Erk extracted from BT-474 cells either untreated or cultured in the presence of vehicle or trastuzumab at ED50 or fulvestrant at ED50 or with a combination of both for 72h.
The figure shows that trastuzumab when used as a single agent decreased the levels of both p-Akt and p-Erk, while fulvestrant raised the levels of both proteins. The combination of both drugs significantly prevented fulvestrant from raising the levels of both proteins. * P<0.05 compared with control group. ** P<0.05 compared with combination group.