. 2017 Jan 3;12(1):e0168960. doi: 10.1371/journal.pone.0168960

Table 3. Effects on ZR-75-1 cell apoptosis treated with trastuzumab and fulvestrant as single agents or with a combination of both.

Groups	Drug concentration	Early apoptosis rate ( $\bar{x} \pm s$ )	Late apoptosis rate ( $\bar{x} \pm s$ )
Control	0	0.0276±0.0144	0.0179±0.0027
Vehicle	0.0045%^a	0.0402±0.0268^b	0.0435±0.0383^b
Trastuzumab	0.65mg/ml	0.0189±0.0215^b	0.0274±0.0233^b
Fulvestrant	45nmol/L	0.0221±0.0245^b	0.0558±0.0148^b
Combination	Tras (0.65mg/ml) + Ful (45nmol/L)	0.0298±0.0151^b ^c ^d	0.0425±0.0389^b ^c ^d

^a Cells in vehicle group were cultured in the presence of the same concentration of absolute ethanol as fulvestrant-treated group.

^b P>0.05 compared with control group.

^c P>0.05 compared with trastuzumab-treated group.

^d P>0.05 compared with fulvestrant-treated group