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. 2016 Dec 30;95(52):e5669. doi: 10.1097/MD.0000000000005669

Figure 1.

Figure 1

The protein–protein interaction (PPI) of identified 28 ERGs by STRING and Cytoscape software, and was also widened by adding 9 partners (BCL2L1, BCL2L11, HSP90AA1, TP53, MCL1, BAD, BIK, BECN1, and IGF1), which had similar physiological function with included DEGs. The intensity of the yellow genes relative with the chondrocyte apoptosis, and the PPI reveals that the 28 ERGs coded protein contributed to the chondrocyte apoptosis and cell death induced by the Ras, PI3K-Akt, and P53 signaling pathway.