Table 1.
Incidence and multiplicity of adenoma and cancer in colon
| Group | Adenoma incidence | Cancer incidence | Adenoma/cancer incidence | Adenoma/cancer multiplicity | Depth of invasion |
|---|---|---|---|---|---|
| 4-week male | |||||
| Control (n = 4) | 0.0 (0/4) | 0.0 (0/4) | 0.0 (0/4) | 0.0 | |
| AOM/DSS (n = 6) | 50.0 (3/6) | 0.0 (0/6) | 50.0 (3/6) | 0.67 ± 0.42 | Mucosa (0) Submucosa (0) |
| P-valuea | 0.200 | 1.000 | 1.000 | ||
| 4-week female | |||||
| Control (n = 5) | 0.0 (0/5) | 0.0 (0/5) | 0.0 (0/5) | 0.0 | |
| AOM/DSS (n = 6) | 16.7 (1/6) | 0.0 (0/6) | 16.7 (1/6) | 0.17 ± 0.17 | Mucosa (0) Submucosa (0) |
| P-valuea | 1.000 | 1.000 | 1.000 | ||
| P-valueb | 0.138 | ||||
| 10-week male | |||||
| Control (n = 5) | 0.0 (0/5) | 0.0 (0/5) | 0.0 (0/5) | 0.0 | |
| AOM/DSS (n = 10) | 0.0 (0/10) | 70.0 (7/10) | 70.0 (7/10) | 4.90 ± 0.87 | Mucosa (6) Submucosa (1) |
| P-valuea | 1.000 | 0.026* | 0.026* | ||
| 10-week female | |||||
| Control (n = 5) | 0.0 (0/5) | 0.0 (0/5) | 0.0 (0/5) | 0.0 | |
| AOM/DSS (n = 10) | 10.0 (1/10) | 50.0 (5/10) | 60.0 (6/10) | 3.50 ± 1.40 | Mucosa (5) Submucosa (0) |
| P-valuea | 1.000 | 0.101 | 0.044* | ||
| P-valueb | 0.235 | ||||
| 16-week male | |||||
| Control (n = 5) | 0.0 (0/5) | 0.0 (0/5) | 0.0 (0/5) | 0.0 | |
| AOM/DSS (n = 10) | 0.0 (0/10) | 60.0 (6/10) | 60.0 (6/10) | 8.30 ± 1.98 | Mucosa (4) Submucosa (2) |
| P-valuea | 1.000 | 0.044* | 0.044* | ||
| 16-week female | |||||
| Control (n = 5) | 0.0 (0/5) | 0.0 (0/5) | 0.0 (0/5) | 0.0 | |
| AOM/DSS (n = 10) | 0.0 (0/10) | 60.0 (6/10) | 60.0 (6/10) | 3.00 ± 0.54 | Mucosa (4) Submucosa (2) |
| P-valuea | 1.000 | 0.044* | 0.044* | ||
| P-valueb | 0.020* | ||||
Values are presented as % (number/subtotal), mean ± SE, or (number) only. AOM, azoxymethane; DSS, dextran sulfate sodium.
a
Between control and AOM/DSS group. Fisher’s exact test.
b
Between AOM/DSS male and female. Mann-Whitney test.
*
Asterisk means statistical significance (P < 0.05).