Table 2.

		Site
		Middle			Margins
Factor	Time	Sorrento + BMA	Vitoss Foam Strip + BMA	Autograft	Sorrento + BMA	Vitoss Foam Strip + BMA	Autograft
Cathepsin-K (CAT-K)	3 weeks	+++	++	+	+	++	+
Alkaline phosphatase (ALP)	3 weeks	++	-	+++	++	++	+++
Matrix metalloproteinase-1 (MMP-1)	3 weeks	++	+	-	-	+	-
Matrix metalloproteinase-13 (MMP-13)	3 weeks	+++	++	++	+++	++	+++
Interleukin-6 (IL-6)	3 weeks	-	-	-	-	-	-
mIgG	3 weeks	-	-	-	-	-	-
Cathepsin-K (CAT-K)	6 weeks	+++	++	+	++	++	+
Alkaline phosphatase (ALP)	6 weeks	-	-	++	+++	++	++
Matrix metalloproteinase-1 (MMP-1)	6 weeks	++	+	-	+	-	-
Matrix metalloproteinase-13 (MMP-13)	6 weeks	+++	+++	+	+++	+++	+
Interleukin-6 (IL-6)	6 weeks	-	-	-	-	-	-
mIgG	6 weeks	-	-	-	-	-	-

Grading was performed for each group at 2 sites–middle of the defect and margin of the defect.

The grading was based on the following criteria

(-) no staining

(+) weak staining up to 50%

(++) moderate staining 50–80%

(+++) strong staining 80–100%.