Table 2. Univariate and Multivariate Cox Models for the Association between Survival and Clinicopathological Factors in Patients with Gastric Cancer.

Variables	Univariate Analysis		Multivariate analysis
	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
Total gastric cancer
Age (≤60 vs. >60 years)	1.54(0.93–2.56)	0.096
Sex (male vs. female)	1.13(0.59–2.17)	0.712
Location (cardiac vs. non-cardiac)	0.93(0.56–1.53)	0.772
Lauren classification (intestinal vs. diffuse)	2.52(1.51–4.20)	0.000	2.00(1.17–3.40)	0.011
Invasive depth (T1, T2 vs. T3, T4)	4.83(1.51–15.43)	0.008	1.81(0.53–6.21)	0.345
Lymph node metastasis (N0 vs. N1-N3)	4.88(2.31–10.30)	0.000	1.49(0.50–4.41)	0.476
TNM stage (I, II vs.III, IV)	4.66(2.45–8.86)	0.000	3.15(1.20–8.31)	0.020
ALDH1A1(negative vs. positive)	1.43(0.85–2.40)	0.179
Sox2(negative vs. positive)	1.83(1.11–3.02)	0.017	2.02(1.20–3.40)	0.008
Cardiac gastric cancer
Age (≤60 vs. >60 years)	1.48(0.65–3.34)	0.350
Sex (male vs. female)	1.66(0.62–4.45)	0.316
Lauren classification (intestinal vs. diffuse)	4.36(1.98–9.56)	0.000	2.93(1.29–6.67)	0.011
Invasive depth (T1, T2 vs. T3, T4)	2.32(0.55–9.81)	0.253
Lymph node metastasis (N0 vs. N1-N3)	6.76(2.34–19.57)	0.000	1.72(0.35–8.34)	0.502
TNM stage (I, II vs.III, IV)	5.47(2.18–13.69)	0.000	2.57(0.71–9.39)	0.152
ALDH1A1(negative vs. positive)	1.20(0.51–2.83)	0.676
Sox2(negative vs. positive)	3.28(1.50–7.15)	0.003	2.44(1.09–5.50)	0.031