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. 2017 Jan 3;12(1):e0169032. doi: 10.1371/journal.pone.0169032

Fig 3. Significant differences in the modulation of the expression of the luciferase reporter gene in FON+, JEG-3, M8 and U251MG cells considering each 3’UTR haplotype independently, with the 1Fter-2R and 1Fter-4R constructions combined.

Fig 3

Points indicate the means and vertical bars indicate the 95% confidence interval. The number of experiments considering each 3’UTR haplotype is indicated between parentheses. KW: Kruskal-Wallis test; * p value <0.05; ** p value < 0.01; *** p value < 0.001. (A) Modulation of luciferase expression in the four cell lines combined. (B) Modulation of luciferase expression in the HLA-G+ (FON + JEG-3) cell lines combined. (C) Modulation of luciferase expression in the HLA-G- (M8 + U251MG) cell lines combined. In (A) and (B) luciferase expression is significantly more intensely downregulated by UTR-5 and UTR-7 than by other haplotypes.