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. 2016 Dec 15;12(12):e1006518. doi: 10.1371/journal.pgen.1006518

Fig 1. Deletion of one Perk allele cooperates with BrafV600E to drive metastatic melanoma.

Fig 1

A) Kaplan-Mayer survival curve of TyrCre+/-;BrafV600ECA/+;Perk+/- mice treated with 4-HT. B) Western blot of melanoma skin lysates from TyrCre+/-;BrafV600ECA/+;Fbxo4;Perk +/+ or TyrCre+/-;BrafV600ECA/+;Perk+/- or Perk-/- mice (blot anti-Perk, p-eIF2α, eIF2α). C) Melanoma from TyrCre+/-;BrafV600ECA/+;Perk+/- mice analyzed by H&E. Scale bars = 50μm.