Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Dec 15;12(12):e1006518. doi: 10.1371/journal.pgen.1006518

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 Pytel et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

Fig 5 — A) Kaplan-Mayer survival curve of Braf^V600ECA/+, Fbxo4 +/- and Perk +/+, +/- or -/- mice treated with 4-Hydroxytamoxifen (4-HT). B) Western blot of melanoma lysates from TyrCreCA/+; Braf^V600ECA/+; Fbxo4 +/-; Perk +/+, Perk+/- or Perk-/- mice C) IHC analysis of skin from TyrCre+/-;Braf^V600ECA/+;Fbxo4 +/-; Perk+/+ or Perk -/- mice; H&E or IHC with antibodies for S100, p-eIF2α, Chop, cyclin D1, p-Akt, CD31 and quantification of staining/staining index (SI) of IHC. Scale bars = 50μm. D) Tumor volume in TyrCre+/-;Braf^V600ECA/+;Pten-/- mice treated with LY-4; p-values analyzed by two-tailed Student t test. E-F) Western blot of melanoma skin lysates from TyrCre+/-; Braf^V600ECA/+;Pten-/- mice treated with LY-4.