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. 2016 Dec 15;12(12):e1006518. doi: 10.1371/journal.pgen.1006518

Fig 6. PERK is active in human melanoma cell lines and is required for melanoma genesis.

Fig 6

A) PERK is functional human melanoma cell lines. B) Dox-dependent PERK knockdown in WM3918 cells. C) WM3918 and WM239A growth in soft agar with or without PERK knockdown, +/- thapsigargin (Tg); V-vector; doxycycline (Dox); shPERK (soft agar); p-values analyzed by two-tailed Student t test D) Clonogenic survival assay of PERK knockdown WM3918 cells treated with thapsigargin (Tg); doxycycline. E) Cell cycle profile of PERK knockdown WM3918 cells.