Figure 7. Cortico-thalamo-basal ganglia circuit organization for striatal subdivisions.

(a–d) Chord diagrams highlighting the relationships between the cortical subregions forming the primary inputs to the (a) dorsomedial, (b) dorsolateral, (c) posterior, and (d) ventral striatal subdivisions respectively. The projection density at the target subregion is indicated by the width of the arc at the target. Corticocortical connections are shown for the afferent and efferent projections of subregions that form the primary input to each striatal subdivision. Primary input regions are shown in darker colors. Darker colored ribbons indicate connections between two primary input subregions, and lighter colored ribbons indicate the connections of a primary input subregion with secondary cortical subregions that do not project to the corresponding striatal subdivision. Connections are shown for projections with a density >15% in the target area. (e) Example coronal sections through the thalamus from anterior to posterior with overlaid thalamocortical and thalamostriatal confidence maps, as described in Figure 5. Each column shows the origin of thalamic projections associated with the four striatal subdivisions shown in Figure 5. Thalamocortical and corticothalamic projections are grouped across the cortical subregions that form the primary inputs of each striatal subdivision, as determined in Figure 7—figure supplement 1 (section positions are the same as in Figure 4a). (f) Nuclear localization for the convergence confidence maps shown in panel e. Values are represented as the fraction of each thalamic nucleus covered by the average of confidence levels 1, 3, and 5 for thalamostriatal projections (magenta), the average of confidence levels 1, 4, and 7 for thalamocortical projections (cyan) and the average of confidence levels 1, 3, and 5 for thalamostriatal projections that lie within the white overlapping volume shown in panel e. The density of subregion-specific corticostriatal projections within each nucleus is shown in green (See Materials and methods for details). TC: thalamocortical confidence maps; TS: thalamostriatal confidence maps; O: overlay of thalamocortical and thalamostriatal confidence maps; CT: corticothalamic projections.

DOI: http://dx.doi.org/10.7554/eLife.19103.024

Figure 7—figure supplement 1. Intracortical interactions across cortical subregions that innervate the four striatal subdivisions.

(a–b) Coverage plots indicating the fraction of each striatal cluster (columns) occupied by either diffuse or dense corticostriatal projections from each cortical subregion (rows), shown here with the striatal voxel dendrogram (bottom) for the four cluster threshold, as determined in Figure 5. (c) Coverage plot indicating the fraction of each subregion specific corticostriatal projection (rows) in each of the striatal clusters for the four cluster threshold (columns), with the striatal voxel dendrogram (bottom). (d–h) Schematic network diagrams indicating the intra-cortical relationships for the cortical subregions that make up the primary inputs to each striatal subdivisions defined by the four cluster threshold. (d) Overview schematic showing the relative locations of cortical subregions on a collapsed sagittal view of the mouse brain (gray). Primary inputs were as follows: ventral subdivision (dark blue): PrL, Sub, IL, Rhi/Tem, and AI; posterior subdivision (green): Aud, Vis, and Rhi/Tem; dorsolateral subdivision (cyan): FrA, M1/2, S1/2, and AI; dorsomedial subdivision (red): d/vACC, Ptl, Rsp, Vis, PrL/MO, and LO/VO. Cortical subregions with that target multiple striatal targets are indicated with multiple colors. Amyg projections met the criteria for primary inputs to all striatal subdivisions and is thus shown in gray. Lines connecting subregions indicate projections having a density >15% in the target area. (e–h) Schematic corticocortical network diagrams highlighting the spatial relationships between the cortical subregions forming the primary inputs to the (g) ventral, (h) posterior, (i) dorsolateral, and (j) dorsomedial subdivision, respectively. Intra-cortical connections are shown for the afferent and efferent projections of subregions that form the primary input to each in striatal subdivision. Connections between two primary inputs are indicated with a colored line, and connections between a primary input subregions and other cortical subregion are indicated with gray lines.

DOI: http://dx.doi.org/10.7554/eLife.19103.025