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The definition of actionable diplotypes is defined as follows: (i) warfarin, CYP2C9 *2 or *3 heterozygote or homozygote with VKORC1 GA or AA genotype and CYP2C9*1 with VKORC1 AA genotype; (ii) clopidogrel, CYP2C19*2, *3 and *6; (iii) codeine, CYP2D6 poor and intermediate metabolizers; (iv) tacrolimus, CYP3A5*1 heterozygote or homozygote.
