Table 3. Allele frequencies in Malay, Chinese and Indian subjects.
Gene | Common allele | Allele frequencies (this study) | Allele frequencies (ExAC) | ||||
---|---|---|---|---|---|---|---|
Malay | Indian | Chinese | Fsta | East Asian | South Asian | ||
CYP2C9 | *2 | 0.000 | 0.042 | 0.002 | 0.026 | 0.000 | 0.046 |
*3 | 0.060 | 0.128 | 0.027 | 0.027 | 0.034 | 0.113 | |
CYP2C19 | *2 | 0.274 | 0.380 | 0.373 | 0.010 | 0.310 | 0.340 |
*3 | 0.028 | 0.011 | 0.037 | 0.005 | 0.067 | 0.004 | |
*6 | 0.000 | 0.000 | 0.005 | 0.003 | 0.001 | 0.000 | |
*17 | 0.024 | 0.151 | 0.010 | 0.070 | ND | ND | |
CYP2D6 | *2 (rs16947) | 0.143 | 0.341 | 0.137 | 0.055 | 0.852 | 0.620 |
*2 (rs1135840) | 0.655 | 0.489 | 0.706 | 0.036 | 0.299 | 0.481 | |
*2A | 0.115 | 0.215 | 0.107 | 0.019 | ND | ND | |
*4 | 0.028 | 0.089 | 0.002 | 0.035 | 0.004 | 0.116 | |
*5 | 0.024 | 0.039 | 0.017 | 0.003 | ND | ND | |
*7 | 0.000 | 0.008 | 0.000 | 0.005 | 0.000 | 0.008 | |
*9 | 0.004 | 0.006 | 0.000 | 0.002 | 0.000 | 0.002 | |
*10 | 0.258 | 0.042 | 0.236 | 0.064 | 0.591 | 0.181 | |
*14 | 0.000 | 0.000 | 0.007 | 0.005 | 0.016 | 0.000 | |
*35 | 0.000 | 0.011 | 0.000 | 0.007 | 0.003 | 0.011 | |
*36 | 0.210 | 0.014 | 0.313 | 0.105 | ND | ND | |
*41 | 0.040 | 0.134 | 0.032 | 0.034 | 0.030 | 0.135 | |
CYP3A5 | *3 | 0.587 | 0.637 | 0.734 | 0.016 | ND | ND |
VKORC1 | *2 | 0.710 | 0.182 | 0.898 | 0.382 | ND | ND |
ND, Not Determined.