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. 2017 Jan 3;12(1):e0168834. doi: 10.1371/journal.pone.0168834

Fig 2. Multistate “illness-death” analysis scheme and results.

Fig 2

This figure describes the risks of transition undergone by trial participants between three states. Of special interest are transitions from the initial state (at inclusion) to either EDSS deterioration (primary outcome) or early treatment discontinuation. Risks are expressed as hazard ratios (HR) (and their 95% confidence intervals), i.e., the risk of transition for the experimental (CPM) group relative to the control (MP) group of patients. When the HR is < 1, the risk of transition is decreased (treatment efficacy), and when it is > 1, the risk of transition is increased.