Table 4.

95% confidence intervals (CI) around the estimate of the probability of a DLT for different combinations of dose levels and performance status.

Age	Dose=33%	Dose=66%	Dose=100%
Performance Status 0
40	(0.005, 0.010, 0.012)	(0.011, 0.020, 0.036)	(0.020, 0.034, 0.058)
50	(0.006, 0.012, 0.023)	(0.014, 0.024, 0.041)	(0.024, 0.040, 0.066)
60	(0.007, 0.014, 0.026)	(0.016, 0.028, 0.047)	(0.028, 0.047, 0.076)
70	(0.008, 0.016, 0.031)	(0.019, 0.033, 0.056)	(0.033, 0.054, 0.090)
80	(0.010, 0.019, 0.038)	(0.022, 0.039, 0.068)	(0.037, 0.064, 0.108)
Performance Status 1
40	(0.009, 0.015, 0.025)	(0.020, 0.029, 0.044)	(0.034, 0.049, 0.069)
50	(0.010, 0.017, 0.028)	(0.025, 0.035, 0.049)	(0.042, 0.057, 0.077)
60	(0.012, 0.020, 0.033)	(0.029, 0.041, 0.056)	(0.051, 0.067, 0.088)
70	(0.014, 0.024, 0.039)	(0.034, 0.048, 0.067)	(0.058, 0.078, 0.104)
80	(0.016, 0.028, 0.047)	(0.038, 0.056, 0.082)	(0.064, 0.091, 0.127)
Performance Status 2
40	(0.011, 0.021, 0.039)	(0.026, 0.043, 0.069)	(0.044, 0.070, 0.110)
50	(0.014, 0.025, 0.044)	(0.032, 0.050, 0.078)	(0.054, 0.082, 0.122)
60	(0.017, 0.029, 0.051)	(0.038, 0.059, 0.090)	(0.064, 0.095, 0.140)
70	(0.019, 0.034, 0.061)	(0.044, 0.068, 0.106)	(0.073, 0.110, 0.163)
80	(0.022, 0.040, 0.073)	(0.049, 0.080, 0.127)	(0.082, 0.128, 0.193)

Number of metastatic sites is always 2 which is the median number of sites (lower CI, estimate, upper CI). Dose is represented as percent of maximum tolerated dose (%MTD).