Table 3.
Crude SVR12 among patients treated with SOF+SMV or SOF+SMV+RBV.
| Population | SOF+SMV | SOF+SMV+RBV | ALL | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n/N | SVR12 | 95% CI | n/N | SVR12 | 95% CI | n/N | SVR12 | 95% CI | ||
| Overall | 105/119 | 88% | (81, 93) | 28/32 | 88% | (71, 96) | 133/151 | 88% | (82, 93) | |
| Tx Experience | Naïve | 51/57 | 89% | (78, 96) | 9/9 | 100% | (66, 100) | 60/66 | 91% | (81, 97) |
| Experienced | 54/62 | 87% | (76, 94) | 19/23 | 83% | (61, 95) | 73/85 | 86% | (77, 92) | |
| Prior PI Failure | 4/8 | 50% | (16, 84) | 3/3 | 100% | (29, 100) | 7/11 | 64% | (31, 89) | |
| Genotype | 1a | 57/67 | 85% | (74, 93) | 17/20 | 85% | (62, 97) | 74/87 | 85% | (76, 92) |
| 1b | 30/32 | 94% | (79, 99) | 9/10 | 90% | (55, 100) | 39/42 | 93% | (81, 99) | |
| Cirrhotic | Yes | 63/74 | 85% | (75, 92) | 20/23 | 87% | (66, 97) | 83/97 | 86% | (77, 92) |
| No | 42/45 | 93% | (82, 99) | 8/9 | 89% | (52, 100) | 50/54 | 93% | (82, 98) | |
| MELD | < 10 | 19/20 | 95% | (75, 100) | 2/3 | 67% | (9, 99) | 21/23 | 91% | (72, 99) |
| ≥ 10 | 6/10 | 60% | (26, 88) | 4/5 | 80% | (28, 99) | 10/15 | 67% | (38, 88) | |
| Genotype: ALL | Cirrhotic Experienced | 33/38 | 87% | (72, 96) | 15/18 | 83% | (59, 96) | 48/56 | 86% | (74, 94) |
| Non-cirrhotic Experienced | 21/24 | 88% | (68, 97) | 4/5 | 80% | (28, 99) | 25/29 | 86% | (68, 96) | |
| Cirrhotic Naive | 30/36 | 83% | (67, 94) | 5/5 | 100% | (48, 100) | 35/41 | 85% | (71, 94) | |
| Non-cirrhotic Naive | 21/21 | 100% | (84, 100) | 4/4 | 100% | (40, 100) | 25/25 | 100% | (86, 100) | |
| Genotype: 1a | Cirrhotic Experienced | 18/22 | 82% | (60, 95) | 9/11 | 82% | (48, 98) | 27/33 | 82% | (65, 93) |
| Non-cirrhotic Experienced | 9/11 | 82% | (48, 98) | 2/3 | 67% | (9, 99) | 11/14 | 79% | (49, 95) | |
| Cirrhotic Naive | 16/20 | 80% | (56, 94) | 4/4 | 100% | (40, 100) | 20/24 | 83% | (63, 95) | |
| Non-cirrhotic Naive | 14/14 | 100% | (77, 100) | 2/2 | 100% | (16, 100) | 16/16 | 100% | (79, 100) | |
| Genotype: 1b | Cirrhotic Experienced | 10/10 | 100% | (69, 100) | 5/6 | 83% | (36, 100) | 15/16 | 94% | (70, 100) |
| Non-cirrhotic Experienced | 8/8 | 100% | (63, 100) | 1/1 | 100% | (3, 100) | 9/9 | 100% | (66, 100) | |
| Cirrhotic Naive | 7/9 | 78% | (40, 97) | 1/1 | 100% | (3, 100) | 8/10 | 80% | (44, 97) | |
| Non-cirrhotic Naive | 5/5 | 100% | (48, 100) | 2/2 | 100% | (16, 100) | 7/7 | 100% | (59, 100) | |