TABLE 1.

Reeves signature model and associated predicted substrates for metagenomic AT domains^a

Substrate or AT domain	Conserved pattern sequences			Predicted substrate(s)
Substratesb
M	(Q/R/D/E)TX(Y/F) (T/A)Q	GHS(L/V/I)GE	H(A/G)FH
mM	R(V/A/I)(D/E)VVQ	GHS(Q/M)GE	YASH
eM	RVDVV(Q/H)	GHSQGE	TAGH
AT domains
Lib4	RTEIAQ	GHSVGE	YAFH	M, mM
Lib7	ETIYTQ	GHSIGE	RAFH	M
Lib10	APSVGL	GHSMGE	VAAH	M, mM

^aReeves signature model (23). The consensus patterns for malonyl, methylmalonyl, and ethylmalonyl are given with all possibilities (indicated in parentheses). Signatures of the metagenomic AT domains were extracted and reported with the deduced substrate(s).

^bM, malonyl; mM, methylmalonyl; eM, ethylmalonyl.