Table 3.

Mean differences (beta, 95% CI) between paternal body mass index and neonatal markers of inflammation and immunoglobulin levels in the Upstate KIDS Study.

Neonatal Biomarkersa	Obese Class II/III		Obese Class I		Overweight
	(>35.0 kg/m2)		(30.0-34.9 kg/m2)		(25.0-29.9 kg/m2)
Total n = 3555	n = 379		n = 666		n = 1551
	Unadjusted	Adjusted	Unadjusted	Adjusted	Unadjusted	Adjusted
Inflammation score	0.08 (−0.08,0.23)	0.07 (−0.09,0.23)	0.03 (−0.09,0.15)	0.05 (−0.07,0.17)	−0.03 (−0.13,0.08)	0.003 (−0.10,0.11)
CRPb	0.01 (−0.08,0.11)	0.004 (−0.10,0.10)	0.01 (−0.07,0.09)	0.01 (−0.07,0.09)	0.005 (−0.06,0.07)	0.02 (−0.04,0.09)
IgEc	0.04 (−0.06,0.14)	0.04 (−0.06,0.15)	−0.02 (−0.10,0.06)	−0.02 (−0.10,0.07)	0.01 (−0.06,0.08)	0.01 (−0.06,0.08)
IgAc	0.002 (−0.06,0.07)	0.02 (−0.05,0.09)	−0.03 (−0.09,0.03)	−0.01 (−0.07,0.05)	−0.01 (−0.06,0.04)	−0.0001 (−0.05,0.05)
IgMc	−0.08 (−0.15,−0.01)	−0.11 (−0.19,−0.04)	−0.05 (−0.11,0.01)	−0.07 (−0.13,−0.01)	−0.07 (−0.12,−0.03)	−0.08 (−0.13,−0.03)
IgG1c	−0.04 (−0.08,0.0005)	−0.03 (−0.07,0.02)	−0.01 (−0.04,0.02)	−0.001 (−0.03,0.03)	0.005 (−0.02,0.03)	0.01 (−0.02,0.04)
IgG2c	−0.01 (−0.10,0.08)	−0.03 (−0.12,0.06)	−0.04 (−0.11,0.03)	−0.06 (−0.13,0.02)	0.02 (−0.03,0.08)	0.01 (−0.04,0.07)
IgG3c	−0.07 (−0.15,0.01)	−0.05 (−0.13,0.04)	−0.07 (−0.12,−0.01)	−0.04 (−0.10,0.02)	−0.03 (−0.08,0.02)	−0.01 (−0.06,0.04)
IgG4c	−0.09 (−0.27,0.08)	−0.03 (−0.21,0.15)	−0.01 (−0.14,0.12)	0.02 (−0.11,0.15)	0.06 (−0.06,0.18)	0.08 (−0.04,0.19)

Abbreviations: CI, confidence interval; CRP, C-reactive protein; TNF, tumor necrosis factor; (IL)-1ra, interleukin-1 receptor antagonist; Ig, immunoglobulin.

Adjusted for maternal age; white race; attainment of college degree or higher; private insurance; smoking and alcohol use during pregnancy; parity; infant plurality; and pre-pregnancy body mass index. Significant differences (P<0.05) are in bold.

^aInfants born to thin and normal weight men (body mass index= <25.0 kg/m2) served as the reference group: n=959.

^blog mg/L

^clog ng/mL