Multi-panel figure of change from baseline (mean and SE bars) in cardiometabolic outcome (hemoglobin A1c [HbA1c] (A); systolic blood pressure [SBP] (B); diastolic blood pressure [DBP] (C); low-density lipoprotein LDL cholesterol (D); high-density lipoprotein (HDL) cholesterol (E); total cholesterol (F); triglycerides (G); and c-peptide oral disposition index [oDI] (H) at month 6, 12 and 24, separately for youth who achieved a drop of ≥7% in percent overweight since baseline vs. those who did not. The ‘*’ indicates a significant difference (P < .001) between the two groups at a particular time point, based on GEE repeated-measures models adjusted for the baseline value of the cardiometabolic outcome, visit, treatment, sex, race-ethnicity, age at baseline and change in percent overweight during run-in. C-peptide oDI based on OGTT data not available at month 12 per study protocol.