Fig. 1.

Time course of lactate (left) and bioactive adrenomedullin (bio-ADM) (right) levels in 90-day survivors (white boxes) and non-survivors (gray boxes). Box and whisker plot: central line = median, box = interquartile range, whiskers = 5th and 95th percentile, circles = outliers. Scatted line upper normal limit (2 mmol/L for lactate and 43 pg/mL for bio-ADM [8]). n = number of samples at each study time point. P values for all comparisons between survivors and non-survivors at each time point were <0.001, except for lactate at 48, 72, and 96 h, and bio-ADM at 0 h with P < 0.05