Table 3.
Outpatient total costs required to manage AEs due to treatment for metastatic melanoma
| Adverse event | Grade | Italy | Spain | Germany | France | Netherlands | UK | Australia | Canada |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | 3 | €1329 | €1443 | €46 | €1285 | €936 | £730 | $890 | $370 |
| 4 | €1281a | €1443 | €46 | €1285b | €936 | £730 | $890 | $370 | |
| Cutaneous squamous cell carcinoma | 3 | €297 | €297 | €406 | €71 | €1063 | £720 | $424 | $205 |
| Diarrhea | 3 | €46 | €134 | €46 | €33 | €86 | £251 | $91 | $162 |
| 4 | €46 | €134b | €46 | €33 | €86 | £126a | $91 | $162 | |
| Diarrhea (immune related) | 3 | €30 | €134 | €46 | €29 | €86 | £251 | $1121 | $162 |
| Dyspnea | 3 | €23 | €99 | €46 | €156 | €188 | £251 | $129b | $194 |
| 4 | €25 | €99b | c | €156b | d | d | $393b | $194 | |
| Elevated liver enzymes | 3 | €47 | €97 | €46 | €28 | €79 | £251 | $304 | $160 |
| 4 | €47 | €97 | €46 | €28 | €79 | £251 | $304 | $160 | |
| Febrile neutropenia | 3 | €436 | €598 | €46 | €29 | €81 | d | d | $258 |
| 4 | €436 | €598 | €46 | €29 | €81 | d | d | $258 | |
| Fever | 3 | €21 | €104 | €46 | €28 | €82 | £251 | $94 | $161 |
| Headache | 3 | €255 | €98 | €46 | €314 | €82 | £251 | $99 | $227 |
| Hypertension | 3 | €46 | €104 | €61 | €30 | €79 | £251 | $97 | $164 |
| Hypophysitis | 3 | €326 | €460 | €46 | €107 | €465 | £251 | $283 | $168 |
| Infection | 3 | €34 | €99 | c | €67 | €81 | £251 | d | $161 |
| 4 | €34 | €99b | c | €67 | d | £251 | d | $161 | |
| Neutropenia | 3 | €89 | €598 | €46 | €28 | €79 | £251 | $141 | $160 |
| 4 | €497 | €755 | €46 | €28 | €79 | d | $210 | $160 | |
| Palmar plantar hyperkeratosis | 3 | €43 | €173 | €46 | €28 | €158 | £126 | $203 | $160 |
| Peripheral neuropathy | 3 | €173 | €1289 | €46 | €28 | €83 | £126 | $152 | $183 |
| 4 | €173 | €1289 | €46 | €28 | €83 | £251 | $218 | $210 | |
| Rash | 3 | €47 | €184 | €46 | €32 | €86 | £251 | $380 | $171 |
| 4 | €47 | €184b | c | €32 | €82e | £251 | $373a | $162f | |
| Vomiting | 3 | €64 | €132 | €76 | €31 | €80 | £251 | $147 | $239 |
| 4 | €64 | €132 | c | €31 | €80 | £251 | d | $239 |
aGrade 4 outpatient treatment is less expensive versus grade 3 because more physicians recommended patients be hospitalized in grade 4; b Although clinicians provided outpatient resource use, they indicated that patients would always be hospitalized; c Never seen; d 100 % inpatient admission; e Physicians suggested more prescription products for grade 3 versus grade 4; f Topical steroids for grade 3 were more expensive than oral steroids for grade 4, as cream can only be purchased per tube