Table 2.
Plasma concentration | CSF concentration | ||||||
---|---|---|---|---|---|---|---|
Added (ng/ml) donepezil | C. V. % | Mean ± SEM | N | Added (ng/ml) donepezil | C. V. % | Mean ± SEM | N |
Inter-day | Inter-day | ||||||
6.25 | 3.23 | 6.2 ± 0.2 | 10 | 6.25 | 4.76 | 6.3 ± 0.3 | 10 |
12.5 | 3.25 | 12.3 ± 0.4 | 10 | 12.5 | 4.84 | 12.4 ± 0.6 | 10 |
25 | 3.13 | 25.6 ± 0.8 | 10 | 25 | 3.54 | 25.4 ± 0.9 | 10 |
50 | 2.23 | 49.4 ± 1.1 | 10 | 50 | 3.82 | 49.7 ± 1.9 | 10 |
100 | 1.73 | 98.3 ± 1.7 | 10 | 100 | 3.29 | 100.3 ± 3.3 | 10 |
Intra-day | Intra-day | ||||||
6.25 | 4.76 | 6.3 ± 0.3 | 3 | 6.25 | 6.45 | 6.2 ± 0.4 | 3 |
12.5 | 4.84 | 12.4 ± 0.6 | 3 | 12.5 | 1.60 | 12.5 ± 0.2 | 3 |
25 | 4.59 | 26.1 ± 1.2 | 3 | 25 | 3.50 | 25.7 ± 0.9 | 3 |
50 | 2.18 | 50.5 ± 1.1 | 3 | 50 | 2.42 | 49.5 ± 1.2 | 3 |
100 | 2.02 | 99.1 ± 2.0 | 3 | 100 | 2.57 | 101.1 ± 2.6 | 3 |